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The mule is a domestic equine hybrid between a donkey and a horse. It is the offspring of a male donkey (a jack) and a female horse (a mare). The horse and the donkey are different species, with different numbers of chromosomes; of the two possible first-generation hybrids between them, the mule is easier to obtain and more common than the hinny, which is the offspring of a male horse (a stallion) and a female donkey (a jenny).

Mules vary widely in size, and may be of any color seen in horses or donkeys. They are more patient, hardier and longer-lived than horses, and are perceived as less obstinate and more intelligent than donkeys.